Artikeln har titeln ”Avian influenza and sialic acid receptors: More than meets the eye?”. Niklas Arnberg kan nås på tel. 090-7858440 (arb)

Avian influenza H5 hemagglutinin binds with high avidity to sialic acid on of the influenza hemagglutinin receptor Sia alpha 2-3Gal on different O-glycan

Coronaviruses (order Nidovirales, family Coronaviridae) are a diverse group of viruses that cause 4 Paramyxoviridae. The α2,3-linked sialic acid in unbranched sugar chains as a receptor. Crys-tal structures of the MuV attachment protein hemagglutinin-neur-aminidase (MuV-HN) alone and in complex with the α2,3-sialylated trisaccharide revealed that in addi tion to the interaction between the MuV-HN active site residues and sial ic acid, other residues, including Sialic acid receptors: focus on their role in influenza infection Guadalupe Ayora-Talavera Virology Laboratory, Center of Regional Research Dr Hideyo Noguchi, Autonomous University of Yucatan, Merida, Yucatan, Mexico Abstract: Receptor-binding specificity is a major determinant of host range, pathogenesis, and interspecies transmission in influenza virus. Among coronaviruses, several members are able to interact with sialic acids. For bovine coronavirus (BCoV) and related viruses, binding to cell surface components containing N-acetyl-9- O-acetylneuraminic acid is essential for initiation of an infection. These viruses resemble influenza C viruses because they share not only the receptor determinant, but also the presence of an acetylesterase The “essential arginine” critical for sialic acid recognition in both Siglec‐14 and Siglec‐5 is present in humans but mutated in almost all great ape alleles.—Angata, T., Hayakawa, T., Yamanaka, M., Varki, A., Nakamura, M. Discovery of Siglec‐14, a novel sialic acid receptor undergoing concerted evolution with Siglec‐5 in primates.

Antigens, CD22. B Lymphocyte Cell Adhesion Molecule. B-Lymphocyte Cell Adhesion Molecule. Initial attachment on cells through primary receptor binding is usually For example, influenza viruses bind to receptors containing sialic acid on the cell surface CONDENSED WORK PLAN: For identification of novel receptors, we plan to of cellular receptor distribution on cells and tissues, iv) that sialic acid containing In a series of publications, we have reported that this virus uses sialic acid as a cellular receptor. Here we demonstrate in vitro that on a molar basis, multivalent av S Hirmo · 2000 · Citerat av 1 — adhesin-receptor analogues, which can inhibit gastric tissue colonisation. H. pylori sialic acid (Sia)-binding surface proteins represent a group of lectin-like av A Berg · 2012 — Nyckelord: Influensavirus, H3N8, häst, hund, receptoruttryck horses and dogs share the same type of sialic acid receptor (SAα2,3Gal) in the epithelium of.

The sialic acid dependence of MAG inhibition was challenged by the recent identification of the Nogo-66 receptor (NgR1) as a high-affinity MAG receptor that supports binding in a sialic acid-independent manner (Domeniconi et al., 2002; Liu et al., 2002).

2009-05-05 · Hello Professor, Thank you for your blog. I have one question about the sialic acid receptors. My understanding is that the avian influenza virus has a preferential binding to alpha(2,3) linked sialic acids, but when it becomes pandemic, in order to transmit from human to human, it can also bind to alpha(2,6) linked sialic acids.

Recently, a subset of immunoglobulin superfamily receptors has been found to behave as sialic acid binding lectins and proposed to define a new class of adhesion receptors known as siglecs.6 Although all members of this family, which include CD22, CD33, myelin-associated glycoprotein (MAG), and sialoadhesin (Sn) share sialic acid binding properties, they differ in the manner in which they

A repetitive DNA element regulates expression of the Helicobacter pylori sialic acid binding adhesin by a rheostat-like mechanism. Åberg, Anna; Gideonsson Artikeln har titeln ”Avian influenza and sialic acid receptors: More than meets the eye?”. Niklas Arnberg kan nås på tel. 090-7858440 (arb) A novel epitope residing in the sialic acid receptor-bindingdomain of VEPGDKITFEATGNL (251-265) of the pandemic flu hemagglutinin wasidentified. generate sialic acid linkages on the distal ends of glycan chains. Glycans cover most mammalian cell surfaces and modulate protein and receptor interactions Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases.

exhibit preferential binding to α2,6- and α2,3-linked sialic acids, respectively (11). The distinct preference for either of the two major types of sialic acid is an important determinant of the influenza virus host range (11). Whether MuV uses a particular sialylated sugar structure as a receptor is unknown. Sialic acid-binding immunoglobulin-like lectin (Siglecs), the receptor of Sia, has been well studied recently [ 12 ]. The Sia-Siglec axis of some immune cells including dendritic cells (DCs), treg cells, B lymphocytes and monocytes is closely related to the inflammation in atherosclerosis [ 13, 14, 15 ]. Most sialic acids which are recognized as receptors are terminal sialic acids attached to a penultimate galactose by either α2,3-linkage or α2,6-linkage.
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Sialic acid recognition remains an interesting and challenging target in molecular receptor design.

H. pylori sialic acid (Sia)-binding surface proteins represent a group of lectin-like av A Berg · 2012 — Nyckelord: Influensavirus, H3N8, häst, hund, receptoruttryck horses and dogs share the same type of sialic acid receptor (SAα2,3Gal) in the epithelium of. av M Al-Onaizi · 2020 · Citerat av 1 — (ix) Other Receptors: Many other receptors implicated in immune response regulation are as well expressed in microglia cells. Among these, the sialic acid-binding We have been screening sialic acid on cancer cells by using a molecular Ohlsson L., Rósen A., Gjörloff Wingren A. B cell receptor signaling suppressor SHP-1 Avhandling: Design and Synthesis of Sialic Acid Conjugates as Inhibitors of Cell surface oligosaccharides serve as cellular receptors for many pathogens, Adenosine receptor/dopamine receptor interactions : Molecular and Sialic acid : A new potential marker of alcohol abuse .
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AND HEALTH SCIENCES; denovirus; cellular receptor; glycosaminoglycan; sialic acid; decoy receptors; tropism; epidemic keratoconjunctivitis; antiviral drugs;

To understand the molecular basis of coronavirus attachment to oligosaccharide receptors, we determined cryo-EM structures of coronavirus OC43 S glycoprotein trimer in isolation and in complex with a 9-O-acetylated sialic acid Sialic acid receptors: focus on their role in influenza infection Guadalupe Ayora-Talavera Virology Laboratory, Center of Regional Research Dr Hideyo Noguchi, Autonomous University of Yucatan, Merida, Yucatan, Mexico Abstract: Receptor-binding specificity is a major determinant of host range, pathogenesis, and interspecies transmission in influenza virus. And sialic acid-modified structures form the key fundamental determinants for a number of receptors with known involvement in cellular adhesiveness and cell trafficking, such as the Selectins and the Siglec families of carbohydrate recognizing receptors.On dendritic cells (DC), sialic acid-modified structures are involved in all their functions and their expression changes along CD22, a negative regulator of B cell antigen receptor signaling, binds glycoconjugates terminating in α2, 6 sialic acid.

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Siglecs are sialic acid‐recognizing receptors of the immunoglobulin (Ig) superfamily expressed on immune cells. Human Siglec‐5, encoded by SIGLEC5 gene, has four extracellular Ig‐like domains and a cytosolic inhibitory motif. We discovered human Siglec‐14 with three Ig‐like domains, encoded by the SIGLEC14 gene, adjacent to SIGLEC5.

Human coronaviruses OC43 and HKU1 are related, yet distinct respiratory pathogens, associated with common colds, but also with severe disease in the frail. Both viruses employ sialoglycan-based receptors with 9- O -acetylated sialic acid (9- O -Ac-Sia) as key component. Here, we identify the 9- O -Ac-Sia–specific receptor-binding site of OC43 S and demonstrate it to be conserved and Sialic Acid Receptors of Viruses 2 Orthomyxoviridae. The orthomyxoviruses are enveloped viruses with a single-stranded, segmented RNA genome of negative 3 Coronaviridae. Coronaviruses (order Nidovirales, family Coronaviridae) are a diverse group of viruses that cause 4 Paramyxoviridae.